Standard difficulty · 20 questions · 40 marks
Show your working for Sections B and C. Answers are on the last page — try every question first!
Chemical Coordination and Integration · AW-11B-CCI-2026-V1 · For parents — fold back or tear off before handing the sheet to your child.
| Q | Answer | Working |
|---|---|---|
| 1 | (d) pituitary | it controls many other glands; it is itself regulated by the hypothalamus |
| 2 | (c) posterior pituitary | — |
| 3 | (d) controls male secondary sexual characters and spermatogenesis | — |
| 4 | (b) hyperthyroidism | — |
| 5 | (c) iodothyronine | — |
| 6 | (c) on the cell membrane | vasopressin is a peptide/protein hormone |
| 7 | (c) FSH | — |
| 8 | (d) A is false, but R is true. | A is false: it is a steroid. R is true. |
| 9 | Non-nutrient chemicals that act as intercellular messengers and are produced in trace amounts by endocrine glands or cells, travelling in the blood to act on target cells. | — |
| 10 | The anterior pituitary; it stimulates the adrenal cortex to make glucocorticoids | — |
| 11 | Thymosins | — |
| 12 | Addison’s disease | — |
| 13 | Amino-acid derivative; on the cell membrane, acting through second messengers | — |
| 14 | Adrenal cortex (deficiency) | — |
| 15 | Cortisol and Aldosterone | — |
| 16 | The pars intermedia of the pituitary; the hypothalamus (through releasing and inhibiting hormones carried by the portal system) | — |
| 17 | Growth hormone: growth (excess causes gigantism in children and acromegaly in adults; deficiency causes dwarfism). Prolactin: growth of mammary glands and milk formation. TSH: stimulates the thyroid. ACTH: stimulates the adrenal cortex to secrete glucocorticoids. LH and FSH (gonadotrophins): stimulate the gonads; in males LH stimulates androgen secretion and FSH with androgens regulates spermatogenesis; in females LH induces ovulation and maintains the corpus luteum, and FSH stimulates the growth of ovarian follicles. MSH (from the pars intermedia): pigmentation of the skin. | — |
| 18 | cortisol: adrenal cortex; controls carbohydrate metabolism and suppresses inflammation and immunity; aldosterone: adrenal cortex; increases reabsorption of Na+ and water and excretion of K+; secretin: small intestine wall; makes the pancreas release water and bicarbonate; growth hormone: anterior pituitary; stimulates growth | — |
| 19 | goitre: iodine deficiency, which enlarges the thyroid; gland: thyroid (iodine deficiency); dwarfism: too little growth hormone in childhood; gland: pituitary (deficiency); diabetes mellitus: lack of insulin or reduced response to it; gland: pancreas: β-cells (insulin deficiency or resistance) | — |
| 20 | insulin: peptide/protein, membrane; triiodothyronine (T3): iodothyronine, intracellular; oestradiol: steroid, intracellular; thyroxine (T4): iodothyronine, intracellular. Membrane-bound receptors work through second messengers (cAMP, Ca2+) to change metabolism; intracellular receptors regulate gene expression. | — |